Epilepsy (Generalized Tonic–Clonic Seizures) – Drug of Choice Tab. Sodium Valproate 500 mg PO BD Dose: Start 10–15 mg/kg/day, increase to 20–30 mg/kg/day in divided doses. Uses First-line drug for generalized tonic–clonic seizures. Also useful in myoclonic and absence seizures. Mechanism of Action ↑ GABA levels → enhances inhibitory transmission. Blocks voltage-gated sodium channels → stabilizes neuronal membranes. Blocks T-type calcium channels → suppresses abnormal discharges. Prescription Tab
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Epilepsy (Generalized Tonic–Clonic Seizures) – Drug of Choice Tab. Sodium Valproate 500 mg PO BD Dose: Start 10–15 mg/kg/day, increase to 20–30 mg/kg/day in divided doses. Uses First-line drug for generalized tonic–clonic seizures. Also useful in myoclonic and absence seizures. Mechanism of Action ↑ GABA levels → enhances inhibitory transmission. Blocks voltage-gated sodium channels → stabilizes neuronal membranes. Blocks T-type calcium channels → suppresses abnormal discharges. Prescription Tab
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Aazer Nawab on Instagram: "Sodium valproate and meropenem (a carbapenem antibiotic) should not be given together because of a serious drug–drug interaction. -Mechanism of Interaction: •Carbapenems (like meropenem, imipenem, ertapenem) markedly reduce serum concentrations of sodium valproate. •This happens because carbapenems inhibit the hydrolysis of valproate-glucuronide back to valproate in the gut and possibly enhance its elimination. •Result: Rapid fall (within 24 hours) in valproate levels,
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Aazer Nawab on Instagram: "Sodium valproate and meropenem (a carbapenem antibiotic) should not be given together because of a serious drug–drug interaction. -Mechanism of Interaction: •Carbapenems (like meropenem, imipenem, ertapenem) markedly reduce serum concentrations of sodium valproate. •This happens because carbapenems inhibit the hydrolysis of valproate-glucuronide back to valproate in the gut and possibly enhance its elimination. •Result: Rapid fall (within 24 hours) in valproate levels,
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