Cardiovascular and cardiometabolic diseases are leading causes of morbidity and mortality worldwide, driven in part by chronic inflammation. Emerging research suggests that the bone marrow ...

Dr Jitesh Neupane discusses his hematoids model and opportunities to study childhood blood disorders and future stem cell therapies.

RECENT research has uncovered key insights into the genetic mechanisms driving age-related clonal haematopoiesis (CH), a condition linked to inflammatory cardiovascular disease and myeloid ...

Hyperthermic Intraperitoneal Chemotherapy in Platinum-Sensitive Recurrent Ovarian Cancer: A Randomized Trial on Survival Evaluation (HORSE; MITO-18) Clonal hematopoiesis (CH) has been associated with ...

ABSTRACT: There is a considerable demand but limited supply for hematopoietic stem cells (HSCs) in clinics. To meet clinical needs of HSCs, new efforts focus on de novo HSCs generation from ...

A RECENT study examining long-term effects of allogeneic hematopoietic cell transplantation (HCT) has provided new insights into the behaviour of clonal haematopoiesis (CH) following transplantation.

Copyright: © 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. Myelodysplastic syndromes ...

New research identifies a larger pool of genes involved in clonal haematopoiesis than previously thought, and their implications for disease and diagnostic tests. New research identifies a larger pool ...

In a recent study published in the journal Nature Genetics, a team of researchers from the United Kingdom (U.K.) and the United States (U.S.) analyzed whole blood samples from a large cohort of U.K.

The bone marrow microenvironment is composed by different specialized niches characterized by the presence of distinct types of haematopoietic stem and progenitor cells, thus establishing a ...

Scientists from Cincinnati Children’s Hospital Medical Center, Massachusetts General Hospital, and elsewhere have been able to pinpoint cells in mouse bone marrow that give rise to specific types of ...

Objectives Ageing and inflammation are associated with clonal haematopoiesis (CH), the emergence of somatic mutations in haematopoietic cells. This study details CH in patients with systemic ...