Former Senator Jeff Flake responded to Tillis' retirement announcement on Sunday, suggesting he could win re-election only by taking positions against his beliefs.

North Carolina Republican U.S. Sen. Thom Tillis made an unexpected decision not to seek a third term. Here’s what the reaction has been.

“Over fifty thousand Americans will die unnecessarily every year,” Sanders warned. “Fifty thousand Americans will die ...

The political battle for a pivotal U.S. Senate seat is officially underway in North Carolina, following Republican Senator ...

McConnell voiced his concern on the heels of Republican Senator Thom Tillis announcing he will not see re-election.

Lara Trump, the wife of Eric Trump and host of Fox News' "My View," teased that she is "considering" a run for U.S. Senate.

Senator Bernie Sanders, I-Vt., also reacted to Tillis' announcement with a criticism of Trump. "I do not agree with N.C. Senator Thom Tillis on much. But he’s right on this," Sanders' post began.