The San Francisco 49ers are 3-1 and stand atop the NFC West due to a tie-breaker over the Seattle Seahawks and Los Angeles Rams, which are also 3-1. Their grip on the division will be threatened on "Thursday Night Football" against the Rams, with one factor posing a particular threat — the team’s inability to run the football.

Brock Purdy will miss the 49ers' "Thursday Night Football" game against the Rams after his toe injury flared up, and Mac Jones will make his third start.

The Los Angeles Rams are coming off a hard-fought Week 4 victory over the Indianapolis Colts to improve to 3-1. Now, on a short week, they’re gearing up for a

The NFC West had its first week of multiple losses. The San Francisco 49ers took control of the division as the only undefeated team, while the LA Rams and Arizona Cardinals suffered their first defeats of the season. No one in the division has more than one loss, but two are 0-1 in the division.

After taking a loss to the Jacksonville Jaguars in Week 5, the San Francisco 49ers will have to overcome adversity on TNF vs. the Rams.