The NF-κB-inducing kinase (NIK), a molecule pivotal for immune system development and function, shows significant yet complex potential as a therapeutic target. The comprehensive review, published by ...
Two decades ago, Professor Shao-Cong Sun first discovered the non-canonical NF-κB pathway mediated by NF-κB-inducing kinase (NIK). Since then, more ...
A new experimental drug, Nerandomilast, has shown potential in reducing lung inflammation and fibrosis in preclinical models of Idiopathic Inflammatory Myopathy–Associated Interstitial Lung Disease ...
Researchers have revealed how a common bacterium, Enterococcus faecalis (E. faecalis), releases lactic acid to acidify its surroundings and suppress the immune-cell signal needed to start a proper ...
Researchers have discovered that mutations in the FOXJ3 gene act as a "master switch" failure, disrupting how the brain ...
Discover how scientists are unlocking the potential of a natural compound, Anemoside B4, to fight inflammation and immune disorders. From its unique discovery process to promising applications in both ...
Inform future clinical development plans, further establishing elraglusib as a potential backbone therapy in difficult-to-treat cancersMechanisms ...
Researchers uncover the protective role of LOXL2 protein in preventing cartilage damage CHENGDU, SICHUAN, CHINA, March ...
Patients with type 2 diabetes who received sodium-glucose cotransporter-2 inhibitors demonstrated a nearly 50% lower risk for systemic autoimmune rheumatic disease vs. those who received dipeptidyl ...
A recent review identifies interleukin-36 (IL-36) as a transformative driver of vascular inflammation, revealing that serum ...
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