While we all love the marquee games on an NFL slate, you can strike fantasy football gold in matchups that feature two struggling teams or a game that may have a lopsided result.

Matchups are the key to fantasy lineup decisions. Here are the most and least favorable for Week 5 at QB, RB, WR and TE.

An all-encompassing look at the matchups to exploit or avoid and lineup locks in fantasy, as well as projected scores for all NFL games.

Jahmyr Gibbs and De'Von Achane lead UPI senior sports writer Alex Butler's Top-50 fantasy football running back rankings for ...

STARTS: Jaylen Waddle (No. 2 WR), Chuba Hubbard (or Rico Dowdle if Hubbard is out), Tetairoa McMillan, Darren Waller (low-end ...

Start ‘Em, Sit 'Em is the ultimate look at the best and worst matchups based on a PPR scoring system in fantasy football.

Josh Allen, Jonathan Taylor, Puka Nacua, and Trey McBride highlight positional rankings for Week 5 of the 2025 NFL season.

TD 2025 debut with the Dolphins visiting the Panthers? Check out all of Michael Florio's TE starts and sits for Week 5 of the NFL fantasy season.

Should you trust Jaxson Dart to build on his impressive first career start? Check out Michael Florio's QB starts and sits for ...

Week 5 fantasy football D/ST start sit recommendations featuring sleeper defenses, streaming options, and matchup analysis for optimal lineup decisions.

When will Aaron Jones return and play? Will Aaron Jones be back again this season? Read the latest Aaron Jones injury updates and return date for Week 5 (2025).

Trying to decide between a couple of closely ranked players this week? Eric Karabell's ranks are here to help.