The contraction of smooth muscle is an essential process underpinning diverse physiological functions ranging from gastrointestinal motility to vascular regulation. At its core, smooth muscle ...

In mice, the drug bortezomib preserved muscle growth and prevented loss of elbow and shoulder motion in conditions resembling cerebral palsy and newborn brachial plexus injury, the most common causes ...

For most of his career, Richard Lieber ’78, Ph.D. ’83, has focused on understanding and solving painful and debilitating muscle contractures that are the result of cerebral palsy, stroke and spinal ...

In cerebral palsy (CP), the spastic motor type is most common, associated with a velocity-dependent increase in muscle stiffness that precedes the development of fixed muscle contracture. In ...

When children experience brachial plexus injury at birth, or are born with cerebral palsy, some of the most disabling problems that follow are muscle contractures, or tightness of muscles, that ...

Clonus is a neurological condition that creates involuntary muscle contractions. This results in uncontrollable, rhythmic, shaking movements. It’s usually brought on by excessive muscle stretching.

S5 mutations disrupt RyR1 channel function, influencing both channel activity and gating mechanisms. This impacts the release of calcium and affects muscle contractions, leading to severe muscle ...

While striations are most prominent in skeletal muscle, they are also present in cardiac muscle, the muscle that makes up the heart. Cardiac muscle fibers, like skeletal muscle fibers, contain ...

Two related studies published today in Nature Metabolism show that a specialized intracellular recycling ...

If your fitness goal is to up the ante on endurance, pack more power into your sprint, or supercharge your strength gains in the gym, it’s worth exploring – what are the different muscle fiber types?