San Francisco 49ers running back Christian McCaffrey is "likely" to play in Sunday's season opener against the Seattle Seahawks, barring a setback with his calf, NFL Network's Ian Rapoport reported Saturday.

San Francisco running back Brian Robinson Jr. revealed he's taking it "day-by-day" while acclimating the 49ers' offensive scheme.

McCaffrey may be healthy enough to be a full participant on days when he is limited, and he may sit out entirely on days when he is healthy enough to be limited. This may be how San Francisco protects him from himself.

Learn which TV channel or how to live stream the NFL Week 1 Seattle Seahawks and San Francisco 49ers game, Sunday, Sept. 7.

San Francisco 49ers fans saw what life was like without star running back Christian McCaffrey last year. So when there's even just the smallest amount of concern over the status of the former Offensive Player of the Year,

There aren't a ton of additions the San Francisco 49ers have made since March. Most of their emphasis was on getting younger, which is why they used all 11 of t

The San Francisco 49ers continue trending the correct direction on the injury front leading up to their Week 1 matchup with the Seattle Seahawks.

The San Francisco 49ers' star running back missed practice today ahead of Week 1 versus the Seahawks. Here's what he said.

The 49ers don't want anyone to know whether Christian McCaffrey will play in their season opener against the Seahawks this Sunday. But he may have provided a hint.