DFS millionaire Mike McClure has also locked in his top picks for the Week 6 NFL DFS main slate, and he's building around Rico Dowdle and Puka Nacua. Get his picks right here.

NFL Week 6 is here and we asked USA TODAY Sports' staff for their top bets for the entire NFL slate. Here are their picks and predictions.

The 49ers (4-1) travel across the country to face the Bucs (4-1), and both teams are coming off entertaining 3-point wins on the road. The 49ers — despite being riddled with injuries on offense — won Thursday night over the Rams as huge underdogs. Mac Jones filled in again for quarterback Brock Purdy and the 49ers offense looked good.

The Chicago Bears and the Washington Commanders face off on Monday Night Football to close out Week 6 of the NFL season.

The Week 6 NFL slate is headlined by a fascinating Sunday night matchup between the Lions and a Chiefs team looking to avoid a 2-4 start.

With Week 6 behind us, here are 16 players to consider starting or sitting in your fantasy leagues as the NFL moves to Week 7.