Looking for upsets? More than one team overcame the odds in Week 6 of the 2025 NFL season. Find out more about those underdogs who came out on top in the article below. FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 41-21 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

The 2025-26 NFL regular season is rolling along, and Week 5 saw plenty of chaos, with multiple favorites of a touchdown or more losing outright. The Arizona Cardinals (-7.5) lost outright 22-21 to the Tennessee Titans in one of the worst losses you'll ever see for those who had the Cardinals in a survivor contest,

The San Francisco 49ers versus the Tampa Bay Buccaneers is one of many strong options on the Week 6 NFL slate. With Week 6 in the NFL upon us, stay on top of the most current betting trends with our preview below.

NFL Week 6 betting spreads, lines, point totals for every game on the NFL Week 6 schedule, with odds for favorites and underdogs in each NFL matchup.

The Chiefs are back in the top three after a win on Sunday over the Lions, who moved down slightly from +800 to +850. Kansas City is now +700 after having a +1000 price last week. The Eagles didn't drop much, going from +700 to +950 after a loss to the Giants to open Week 6. The big moves have come in the middle of the pack.

Two games remain in Week 6 of the 2025 NFL season, and Buffalo Bills quarterback Josh Allen (the favorite to win NFL MVP) has yet to play. But, Allen is losing

Find the best NFL parlays for every week of the 2025-26 season. Learn how NFL parlays work, when to use them, where to bet them and the top bonuses available.