NFL Week 4 kicks off Thursday night, as the Cardinals Bills host the Seahawks. Here are the lines for every Week 4 matchup at DraftKings Sportsbook as of Sept. 28. This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

Get the opening NFL Week 4 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Sept. 25, 2025.

NFL Week 4 betting spreads, lines, point totals for every game on the NFL Week 4 schedule, with odds for favorites and underdogs in each NFL matchup.

The Week 4 Thursday Night Football matchup will feature a battle between 2-1 NFC West squads, both hoping to rise up the division standings. On one side are the Seahawks, whose only loss was to undefeated San Francisco in Week 1. On the other side are the Cardinals, who fell to the Niners in Week 3.

There are a number of intriguing matchups on the Week 7 NFL schedule, including Eagles vs. Vikings (+2.5), Packers vs. Cardinals (+6.5), Commanders vs. Cowboys (+1.5) and Buccaneers vs. Lions (-5.5) on 'Monday Night Football.

The New York Giants head to Mile High to face the Denver Broncos in Week 7. Here's how to watch and stream this game on Sunday afternoon.