Get the opening NFL Week 4 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Sept. 25, 2025.

One week after some stunning developments, like the Cleveland Browns upsetting the Green Bay Packers and the Philadelphia Eagles surviving the Los Angeles Rams with a walk-off field goal block, we've got another slate full of intriguing action in Week 4.

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With the Ravens struggling out of the gate at 1-3, Jackson’s odds have fallen to 10/1, which are the fourth-best odds on the board. Speaking of those Ravens.

Bengals vs. Broncos Prediction: Can Bo Nix, Broncos Bounce Back Against Struggling Bengals? The Monday night doubleheader wraps up out west on ABC with the Denver Broncos hosting the Cincinnati Bengals. Bo Nix and the Broncos enter the matchup at 1-2 ...

There are a number of intriguing matchups on the Week 7 NFL schedule, including Eagles vs. Vikings (+2.5), Packers vs. Cardinals (+6.5), Commanders vs. Cowboys (+1.5) and Buccaneers vs. Lions (-5.5) on 'Monday Night Football.

Exploring the intense NFL game between Green Bay and Arizona, with questions about the Cardinals' quarterback situation and the Packers' recent performance.