The retirement of veteran edge rusher and three time Pro Bowler Za’Darius Smith from the NFL earlier this week, after 11 years in the league, has arguably thrown a bit of a spanner in the works to the Philadelphia Eagles’ defensive personnel.

See which NFL teams boast the league’s best defenses through Week 4, led by Myles Garrett and the Cleveland Browns

The Falcons' defense looked forward to the challenge of shutting down the Bills' offense, and they exceeded expectations, holding them to a season low 14 points. In fact, the Bills have not been held to 14 or fewer points with Josh Allen as their starter since Week 4 of 2024, when they scored just 10 points against the Baltimore Ravens.

Statistically, the Denver Broncos have the best defense in the NFL, and it could be getting even better this weekend. Linebacker Dre Greenlaw is eligible to come off IR against the New York Giants (2-4) on Sunday after recovering from a quadriceps injury that has sidelined him since summertime.

The Broncos sacked Jets quarterback Justin Fields nine times on Sunday, giving Denver an NFL-leading total of 30 sacks this season.

The Cowboys defense has been under fire all season, and after another poor performance, they are the laughing stock of the NFL and morning sports talk shows.

The Denver Broncos have assembled the best defensive line in the entire NFL. They currently lead the league with 30 sacks, and are on pace to shatter the record set by the Chicago Bears in 1984.

I hate to go on an “Old Man Yells at Clouds” rant but I have to at this point. I will never be one to criticize NFL players for hosting a podcast or trying to monetize their brand with an active social media presence.

Former NFL player Mark Sanchez is facing multiple charges after an altercation led to him being stabbed, however, the person who stabbed Sanchez claims it was in self-defense. In this week's Ask Isaacs,

The Cowboys are the NFL's worst on third down. That's when Jayden Daniels struggles most. One side or the other could get right on Sunday.