Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

Scientists usually study the molecular machinery that controls gene expression from the perspective of a linear, two-dimensional genome—even though DNA and its bound proteins function in three ...

Researchers found how the INO80 protein moves nucleosomes to specific positions that are important for gene regulation and DNA replication INO80 uses a unique mechanism for moving nucleosomes that ...

Nucleotide synthesis-the production of the basic components of DNA and RNA-is essential for cell growth and division. In most animal cells, this process depends closely on properly functioning ...

Researchers at The University of Texas MD Anderson Cancer Center have shown that DNA inflexibility, or rigidity, inside the nucleosome regulates the positioning of INO80. This highlights that the ...