The San Francisco 49ers are playing a marquee Week 18 clash against NFC West rival Seattle Seahawks on Saturday night. For the 'Niners to pick up a massive win, they'll need their superstars to deliver, particularly Christian McCaffrey and George Kittle helping out Brock Purdy.

After being limited to just four games last season due to multiple injuries, McCaffrey has returned to top form in 2025. He’s played in all 16 games for the Niners this term, producing 303 carries for 1,179 yards and 10 touchdowns. He’s also caught 96 passes for 890 yards and seven receiving TDs.

The San Francisco 49ers are heading into the most important game of their season this Saturday. Week 18 brings a winner-take-all clash with the Seattl.

Week 18 vs Seahawks as Christian McCaffrey, Trent Williams, and George Kittle push to return for San Francisco.

Left tackle Trent Williams has missed practice this week with a hamstring injury and has been listed as questionable to play. Tight end George Kittle (ankle) has the same designation, but said this week that he plans to play after missing Week 17's win over the Bears.

Part of the San Francisco 49ers' offensive struggles Saturday stemmed from their inability to get the ball into Christian McCaffrey's hands.

The San Francisco 49ers will look to get their offense going in their Wild Card Round playoff game against the Philadelphia Eagles on Jan. 11. Moreover, all eyes will be on Christian McCaffrey to see if the veteran can have a bounce-back performance.