Sphingolipids are ubiquitous components of membranes and function as bioactive lipid signaling molecules. Here, through genetic screening and lipidomics analyses, we find that the endoplasmic ...

The type 1 ryanodine receptor (RyR1) is an important calcium release channel in skeletal muscles essential for muscle contraction. It mediates calcium release from the sarcoplasmic reticulum, a ...

Researchers at the University Medical Center Göttingen (UMG) have shown how a minimal change in a single ion channel increases the sensitivity of sensory cells in the inner ear. Even soft sounds, such ...

Calcium homeostasis, involving the flow of calcium ions within cells, is essential for cell signaling and function. Importantly, calcium enters the cellular powerplants known as mitochondria, where it ...